EIF4G2 [The Human Chemical-Genetic Interaction Map Project]

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======= EIF4G2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EIF4G2
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation initiation factor 4 gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1982|1982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78344|P78344]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EIF4G2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EIF4G2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MIF4G|
|W2|
|MA3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eukaryotic translation initiation factor 4F complex|
|translation factor activity, RNA binding|
|translation initiation factor activity|
|regulation of translational initiation|
|negative regulation of autophagy|
|cell-cell adherens junction|
|translational initiation|
|cell cycle arrest|
|mRNA binding|
|positive regulation of cell growth|
|negative regulation of cellular catabolic process|
|positive regulation of growth|
|cadherin binding|
|negative regulation of catabolic process|
|regulation of autophagy|
|regulation of translation|
|translation|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|regulation of cell growth|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|negative regulation of cell cycle|
|regulation of growth|
|cellular amide metabolic process|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|cell cycle process|
|cell death|
|regulation of cell cycle|
|cell cycle|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.3|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.24|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.09|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.08|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.8|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.79|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.71|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.72|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.77|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.78|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.81|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.97|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.99|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.09|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.26|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.55|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.65|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.67|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.73|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prrc2c|PRRC2C]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 177/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|15/28|
|bone|7/26|
|breast|14/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|5/21|
|liver|11/20|
|lung|17/75|
|lymphocyte|6/16|
|ovary|6/26|
|pancreas|0/24|
|peripheral nervous system|6/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2145
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EIF4G2 Expression in NALM6 Cells: 10.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>