EIF4G2

Entrez Summary: N/A
UniProt Summary: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. {ECO:0000269|PubMed:11511540, ECO:0000269|PubMed:11943866, ECO:0000269|PubMed:9032289, ECO:0000269|PubMed:9049310}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hippuristanol 0.12μM R08 exp488	-2.3
Hippuristanol 0.12μM R08 exp489 no dilution day6	-2.24
Taxol 0.004μM R03 exp103	-2.09
Centrinone 0.5μM R07 exp343	-2.08
GSK461364A 0.005μM R03 exp125	-1.8
Nocodazole 0.2μM R00 exp24	-1.79
Tunicamycin 0.04μM R07 exp418	-1.71
Dimethyl-Sulfoxide 1pc R03 exp120	1.72
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.77
LY2090314 0.003μM R08 exp500 no dilution day6	1.78
CAY10603 0.55μM R08 exp467	1.81
Pyridostatin 4μM R05 exp240	1.97
LB-100 4.1μM R02 exp72	1.99
Radicicol 0.16μM R05 exp242	2
ML-792 0.2μM R08 exp505	2.09
Salinomycin 3.5μM R08 exp521	2.26
Lead acetate 2000μM R08 exp498 no dilution day6	2.55
Lead acetate 2000μM R08 exp497	2.65
Actinomycin-D 0.001μM R00 exp3	2.67
Bortezomib 0.005μM R00 exp6	2.73
Vincristine 0.0005μM R04 exp190	3.36

Global Fraction of Cell Lines Where Essential: 177/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	7/28
blood	15/28
bone	7/26
breast	14/33
central nervous system	10/56
cervix	0/4
colorectal	1/17
esophagus	2/13
fibroblast	0/1
gastric	4/16
kidney	5/21
liver	11/20
lung	17/75
lymphocyte	6/16
ovary	6/26
pancreas	0/24
peripheral nervous system	6/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	4/29
uterus	2/5

Expression Distribution

eukaryotic translation initiation factor 4F complex
translation factor activity, RNA binding
translation initiation factor activity
regulation of translational initiation
negative regulation of autophagy
cell-cell adherens junction
translational initiation
cell cycle arrest
mRNA binding
positive regulation of cell growth
negative regulation of cellular catabolic process
positive regulation of growth
cadherin binding
negative regulation of catabolic process
regulation of autophagy
regulation of translation
translation
regulation of cellular amide metabolic process
peptide biosynthetic process
regulation of cell growth
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
negative regulation of cell cycle
regulation of growth
cellular amide metabolic process
regulation of cellular catabolic process
regulation of catabolic process
cell cycle process
cell death
regulation of cell cycle
cell cycle
RNA binding
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane
gene expression