ELAC1

Entrez Summary: N/A
UniProt Summary: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Lactamase B 2
Lactamase B

3-tRNA processing endoribonuclease activity
endonucleolytic cleavage involved in tRNA processing
tRNA 3-trailer cleavage, endonucleolytic
tRNA 3-trailer cleavage
tRNA 3-end processing
ncRNA 3-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA 3-end processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression