ELOVL2

Gene Information

Official Symbol: ELOVL2
Official Name: ELOVL fatty acid elongase 2
Aliases and Previous Symbols: N/A
Entrez ID: 54898
UniProt: Q9NXB9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n- 6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:20937905}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12903
Expression level (log2 read counts): 4.71

Expression Distribution

fatty acid elongation, polyunsaturated fatty acid
very-long-chain 3-ketoacyl-CoA synthase activity
fatty acid elongase activity
3-oxo-lignoceronyl-CoA synthase activity
fatty acid elongation, unsaturated fatty acid
3-oxo-cerotoyl-CoA synthase activity
fatty acid elongation, monounsaturated fatty acid
3-oxo-arachidoyl-CoA synthase activity
fatty acid elongation, saturated fatty acid
alpha-linolenic acid metabolic process
very long-chain fatty acid biosynthetic process
fatty acid elongation
linoleic acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty-acyl-CoA metabolic process
very long-chain fatty acid metabolic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
unsaturated fatty acid biosynthetic process
thioester biosynthetic process
acyl-CoA biosynthetic process
ribonucleoside bisphosphate biosynthetic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
sphingolipid biosynthetic process
fatty acid derivative biosynthetic process
thioester metabolic process
acyl-CoA metabolic process
integral component of endoplasmic reticulum membrane
unsaturated fatty acid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
nucleoside bisphosphate metabolic process
purine nucleoside bisphosphate metabolic process
ribonucleoside bisphosphate metabolic process
coenzyme biosynthetic process
purine ribonucleotide biosynthetic process
sphingolipid metabolic process
purine nucleotide biosynthetic process