EME2

Entrez Summary: N/A
UniProt Summary: Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. {ECO:0000269|PubMed:17289582}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Holliday junction resolvase complex
crossover junction endodeoxyribonuclease activity
intra-S DNA damage checkpoint
resolution of meiotic recombination intermediates
meiotic chromosome separation
replication fork processing
chromosome separation
DNA-dependent DNA replication maintenance of fidelity
reciprocal meiotic recombination
homologous recombination
meiotic chromosome segregation
mitotic DNA damage checkpoint
mitotic DNA integrity checkpoint
meiosis I
meiosis I cell cycle process
DNA-dependent DNA replication
DNA damage checkpoint
DNA integrity checkpoint
meiotic nuclear division
mitotic cell cycle checkpoint
meiotic cell cycle process
double-strand break repair
cell cycle checkpoint
DNA replication
nuclear chromosome segregation
DNA recombination
meiotic cell cycle
nuclear chromatin
chromosome segregation
nuclear division
nucleic acid phosphodiester bond hydrolysis
negative regulation of mitotic cell cycle
organelle fission
DNA repair
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
DNA metabolic process
cellular response to DNA damage stimulus