EMR2 [The Human Chemical-Genetic Interaction Map Project]

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======= EMR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ADGRE2
  * **<color #00a2e8>Official Name</color>**: adhesion G protein-coupled receptor E2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=30817|30817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHX3|Q9UHX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|7tm 2|
|EGF CA|
|EGF|
|cEGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leading edge membrane|
|chondroitin sulfate binding|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|regulation of mast cell activation|
|regulation of leukocyte degranulation|
|regulation of myeloid leukocyte mediated immunity|
|granulocyte chemotaxis|
|ruffle membrane|
|granulocyte migration|
|myeloid leukocyte migration|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|leukocyte chemotaxis|
|cAMP-mediated signaling|
|regulation of regulated secretory pathway|
|cyclic-nucleotide-mediated signaling|
|regulation of leukocyte mediated immunity|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|positive regulation of immune effector process|
|regulation of exocytosis|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|second-messenger-mediated signaling|
|regulation of intracellular transport|
|leukocyte migration|
|regulation of immune effector process|
|inflammatory response|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|regulation of leukocyte activation|
|regulation of cell activation|
|calcium ion binding|
|G protein-coupled receptor activity|
|regulation of secretion by cell|
|regulation of secretion|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|cell migration|
|localization of cell|
|cell motility|
|regulation of immune response|
|positive regulation of immune system process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|regulation of immune system process|
|intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.99|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.8|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-1.78|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.77|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.81|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17888
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMR2 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>