EMR2

Entrez Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-1.99
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.8
Azithromycin 100μM R08 exp452	-1.78
Mdivi-1 15μM R05 exp217	1.77
GSK-J4 1μM R07 exp362	1.81
Caffeine 2600μM R08 exp463	1.87

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leading edge membrane
chondroitin sulfate binding
regulation of mast cell degranulation
regulation of mast cell activation involved in immune response
regulation of mast cell activation
regulation of leukocyte degranulation
regulation of myeloid leukocyte mediated immunity
granulocyte chemotaxis
ruffle membrane
granulocyte migration
myeloid leukocyte migration
adenylate cyclase-activating G protein-coupled receptor signaling pathway
leukocyte chemotaxis
cAMP-mediated signaling
regulation of regulated secretory pathway
cyclic-nucleotide-mediated signaling
regulation of leukocyte mediated immunity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell chemotaxis
positive regulation of immune effector process
regulation of exocytosis
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
second-messenger-mediated signaling
regulation of intracellular transport
leukocyte migration
regulation of immune effector process
inflammatory response
regulation of vesicle-mediated transport
chemotaxis
taxis
regulation of leukocyte activation
regulation of cell activation
calcium ion binding
G protein-coupled receptor activity
regulation of secretion by cell
regulation of secretion
regulation of cellular localization
cell adhesion
biological adhesion
cell migration