EMX1 [The Human Chemical-Genetic Interaction Map Project]

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======= EMX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: EMX1
  * **<color #00a2e8>Official Name</color>**: empty spiracles homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2016|2016]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04741|Q04741]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=EMX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20EMX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebral cortex regionalization|
|regulation of oligodendrocyte progenitor proliferation|
|radial glial cell differentiation|
|telencephalon regionalization|
|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|
|cerebral cortex neuron differentiation|
|forebrain regionalization|
|brain morphogenesis|
|neuroepithelial cell differentiation|
|neuron projection extension|
|developmental cell growth|
|regulation of neural precursor cell proliferation|
|post-embryonic development|
|cell growth|
|columnar/cuboidal epithelial cell differentiation|
|developmental growth involved in morphogenesis|
|regulation of gliogenesis|
|cerebral cortex development|
|glial cell differentiation|
|pallium development|
|central nervous system neuron differentiation|
|homeostasis of number of cells|
|gliogenesis|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|telencephalon development|
|regionalization|
|in utero embryonic development|
|forebrain development|
|developmental growth|
|growth|
|sequence-specific DNA binding|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|epithelial cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|nucleolus|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|response to drug|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.02|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.81|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.78|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.94|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='EMX1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>