EMX1

Entrez Summary: N/A
UniProt Summary: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Quercetin 20μM R08 exp517	-2.02
Etoposide 1μM R00 exp19	-1.81
S-DABN 8μM R03 exp112	1.78
Deguelin 0.05μM R02 exp69	1.94
Docosahexaenoic-acid 50μM R07 exp356	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebral cortex regionalization
regulation of oligodendrocyte progenitor proliferation
radial glial cell differentiation
telencephalon regionalization
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
cerebral cortex neuron differentiation
forebrain regionalization
brain morphogenesis
neuroepithelial cell differentiation
neuron projection extension
developmental cell growth
regulation of neural precursor cell proliferation
post-embryonic development
cell growth
columnar/cuboidal epithelial cell differentiation
developmental growth involved in morphogenesis
regulation of gliogenesis
cerebral cortex development
glial cell differentiation
pallium development
central nervous system neuron differentiation
homeostasis of number of cells
gliogenesis
DNA-binding transcription repressor activity, RNA polymerase II-specific
telencephalon development
regionalization
in utero embryonic development
forebrain development
developmental growth
growth
sequence-specific DNA binding
pattern specification process
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
RNA polymerase II proximal promoter sequence-specific DNA binding
cell part morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
neuron projection development