ENDOG

Gene Information

Official Symbol: ENDOG
Official Name: endonuclease G
Aliases and Previous Symbols: N/A
Entrez ID: 2021
UniProt: Q14249
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008].
UniProt Summary: Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17304
Expression level (log2 read counts): 3.52

Expression Distribution

neuron death in response to oxidative stress
exodeoxyribonuclease activity
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of hydrogen peroxide-induced cell death
positive regulation of apoptotic DNA fragmentation
positive regulation of DNA catabolic process
positive regulation of response to reactive oxygen species
single-stranded DNA endodeoxyribonuclease activity
regulation of hydrogen peroxide-mediated programmed cell death
regulation of apoptotic DNA fragmentation
positive regulation of cellular response to drug
regulation of DNA catabolic process
positive regulation of execution phase of apoptosis
positive regulation of oxidative stress-induced cell death
apoptotic DNA fragmentation
positive regulation of cellular response to oxidative stress
positive regulation of response to oxidative stress
cell death in response to oxidative stress
regulation of hydrogen peroxide-induced cell death
DNA catabolic process, endonucleolytic
apoptotic nuclear changes
cellular component disassembly involved in execution phase of apoptosis
endoribonuclease activity
DNA catabolic process
positive regulation of response to drug
regulation of response to reactive oxygen species
regulation of cellular response to drug
endonuclease activity
regulation of execution phase of apoptosis
neuron death
execution phase of apoptosis
regulation of oxidative stress-induced cell death
cellular response to glucose stimulus
cellular response to hexose stimulus
cellular response to monosaccharide stimulus
regulation of cellular response to oxidative stress
cellular response to carbohydrate stimulus
RNA phosphodiester bond hydrolysis, endonucleolytic
cellular response to calcium ion
regulation of response to oxidative stress