ENO3

Entrez Summary: This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010].
UniProt Summary: Appears to have a function in striated muscle development and regeneration.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Enolase N
Enolase C

phosphopyruvate hydratase activity
phosphopyruvate hydratase complex
canonical glycolysis
glucose catabolic process to pyruvate
NADH regeneration
glycolytic process through fructose-6-phosphate
glycolytic process through glucose-6-phosphate
glucose catabolic process
skeletal muscle tissue regeneration
NADH metabolic process
glycolytic process
ATP generation from ADP
gluconeogenesis
NAD metabolic process
hexose biosynthetic process
ADP metabolic process
hexose catabolic process
monosaccharide biosynthetic process
nucleoside diphosphate phosphorylation
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
nucleotide phosphorylation
purine ribonucleoside diphosphate metabolic process
tissue regeneration
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
glucose metabolic process
carbohydrate catabolic process
carbohydrate biosynthetic process
hexose metabolic process
regeneration
monosaccharide metabolic process
ATP metabolic process
magnesium ion binding
aging
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process