ENTPD2

Entrez Summary: The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
UniProt Summary: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent. The order of activity with different substrates is ATP > GTP > CTP = ITP > UTP » ADP = UDP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

purine nucleoside diphosphate catabolic process
purine ribonucleoside diphosphate catabolic process
nucleoside-diphosphatase activity
ribonucleoside diphosphate catabolic process
nucleoside-triphosphatase activity
nucleoside diphosphate catabolic process
nucleobase-containing small molecule catabolic process
purine ribonucleoside diphosphate metabolic process
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
nucleoside phosphate catabolic process
nucleoside diphosphate metabolic process
basement membrane
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
platelet activation
blood coagulation
coagulation
hemostasis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleoside phosphate metabolic process
wound healing
organic cyclic compound catabolic process
regulation of body fluid levels
nucleobase-containing small molecule metabolic process
response to wounding
small molecule biosynthetic process
organophosphate metabolic process
endoplasmic reticulum membrane
cell activation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
G protein-coupled receptor signaling pathway
ATP binding