ENTPD3

Entrez Summary: This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014].
UniProt Summary: Has a threefold preference for the hydrolysis of ATP over ADP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

8-oxo-dGTP phosphohydrolase activity
dGTP phosphohydrolase activity
dUTP phosphohydrolase activity
dATP phosphohydrolase activity
dCTP phosphohydrolase activity
GTP phosphohydrolase activity
dTTP phosphohydrolase activity
nucleoside-diphosphatase activity
nucleoside-triphosphatase activity
nucleoside diphosphate catabolic process
nucleoside triphosphate catabolic process
nucleobase-containing small molecule catabolic process
nucleoside phosphate catabolic process
nucleoside diphosphate metabolic process
nucleoside triphosphate metabolic process
nucleobase-containing small molecule biosynthetic process
organophosphate catabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
small molecule biosynthetic process
organophosphate metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process