EPGN
Gene Information
- Official Symbol: EPGN
- Official Name: epithelial mitogen
- Aliases and Previous Symbols: N/A
- Entrez ID: 255324
- UniProt: Q6UW88
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. {ECO:0000269|PubMed:15611079}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of epidermal growth factor-activated receptor activity |
| regulation of epidermal growth factor-activated receptor activity |
| positive regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of ERBB signaling pathway |
| epidermal growth factor receptor binding |
| positive regulation of signaling receptor activity |
| negative regulation of epidermal growth factor receptor signaling pathway |
| epidermal growth factor receptor signaling pathway |
| negative regulation of ERBB signaling pathway |
| positive regulation of mitotic nuclear division |
| clathrin-coated vesicle membrane |
| positive regulation of protein tyrosine kinase activity |
| positive regulation of nuclear division |
| ERBB signaling pathway |
| regulation of epidermal growth factor receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| positive regulation of mitotic cell cycle |
| activation of MAPK activity |
| growth factor activity |
| positive regulation of protein kinase B signaling |
| regulation of mitotic nuclear division |
| regulation of signaling receptor activity |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of nuclear division |
| regulation of protein kinase B signaling |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of MAP kinase activity |
| positive regulation of cell cycle process |
| angiogenesis |
| activation of protein kinase activity |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| MAPK cascade |
| positive regulation of cell cycle |
| signal transduction by protein phosphorylation |
| blood vessel morphogenesis |
| blood vessel development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| tube morphogenesis |
| positive regulation of transferase activity |
| enzyme linked receptor protein signaling pathway |
| regulation of MAPK cascade |
| regulation of cell cycle process |
| regulation of protein kinase activity |
| tube development |
| membrane organization |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15714
- Expression level (log2 read counts): -2.35
Expression Distribution
EPGN Expression in NALM6 Cells: -2.35
