ESRP1

Entrez Summary: N/A
UniProt Summary: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. {ECO:0000269|PubMed:19285943}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifuroxazide 5μM R03 exp102	-1.78
Temozolomide 200μM R04 exp189	1.84

regulation of inner ear auditory receptor cell fate specification
regulation of inner ear auditory receptor cell differentiation
regulation of inner ear receptor cell differentiation
regulation of mechanoreceptor differentiation
regulation of cell fate specification
regulation of cell fate commitment
regulation of epidermal cell differentiation
fibroblast growth factor receptor signaling pathway
regulation of epidermis development
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of RNA splicing
regulation of epithelial cell differentiation
mRNA binding
nuclear body
RNA splicing
mRNA processing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
regulation of neuron differentiation
mRNA metabolic process
enzyme linked receptor protein signaling pathway
regulation of neurogenesis
RNA processing
regulation of nervous system development
regulation of cell development
cellular response to endogenous stimulus
response to endogenous stimulus
generation of neurons
neurogenesis
RNA metabolic process
regulation of cell differentiation
gene expression