ETF1 [The Human Chemical-Genetic Interaction Map Project]

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======= ETF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ETF1
  * **<color #00a2e8>Official Name</color>**: eukaryotic translation termination factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2107|2107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62495|P62495]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ETF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ETF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269|PubMed:7990965}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eRF1 1|
|eRF1 2|
|eRF1 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation termination factor activity|
|translation release factor activity, codon specific|
|cytoplasmic translational termination|
|translation release factor complex|
|translation release factor activity|
|regulation of translational termination|
|sequence-specific mRNA binding|
|ribosome binding|
|cytoplasmic translation|
|translational termination|
|regulation of protein complex disassembly|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|protein methylation|
|protein alkylation|
|cellular protein complex disassembly|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|protein-containing complex disassembly|
|RNA catabolic process|
|macromolecule methylation|
|methylation|
|regulation of translation|
|nucleobase-containing compound catabolic process|
|translation|
|cellular component disassembly|
|regulation of cellular amide metabolic process|
|peptide biosynthetic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|amide biosynthetic process|
|peptide metabolic process|
|mRNA metabolic process|
|cellular amide metabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.71|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.71|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.8|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.03|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.06|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 846
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ETF1 Expression in NALM6 Cells: 7.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>