ETF1

Entrez Summary: N/A
UniProt Summary: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. {ECO:0000269|PubMed:7990965}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 739/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

translation termination factor activity
translation release factor activity, codon specific
cytoplasmic translational termination
translation release factor complex
translation release factor activity
regulation of translational termination
sequence-specific mRNA binding
ribosome binding
cytoplasmic translation
translational termination
regulation of protein complex disassembly
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
protein methylation
protein alkylation
cellular protein complex disassembly
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
protein-containing complex disassembly
RNA catabolic process
macromolecule methylation
methylation
regulation of translation
nucleobase-containing compound catabolic process
translation
cellular component disassembly
regulation of cellular amide metabolic process
peptide biosynthetic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
amide biosynthetic process
peptide metabolic process
mRNA metabolic process
cellular amide metabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
organonitrogen compound biosynthetic process