EVI2B

Entrez Summary: N/A
UniProt Summary: Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor cells. {ECO:0000269|PubMed:28186500}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BAY-598 4μM R05 exp220	1.9
FBS-Wisent 0.1 R07 exp426	1.9

positive regulation of neutrophil differentiation
regulation of neutrophil differentiation
positive regulation of granulocyte differentiation
regulation of stem cell division
regulation of granulocyte differentiation
negative regulation of cell cycle arrest
positive regulation of myeloid leukocyte differentiation
myeloid cell development
positive regulation of myeloid cell differentiation
regulation of cell cycle arrest
regulation of myeloid leukocyte differentiation
positive regulation of leukocyte differentiation
regulation of cell division
positive regulation of hemopoiesis
myeloid cell differentiation
regulation of myeloid cell differentiation
regulation of leukocyte differentiation
negative regulation of cell cycle process
positive regulation of cell cycle
regulation of hemopoiesis
hemopoiesis
negative regulation of cell cycle
hematopoietic or lymphoid organ development
immune system development
regulation of cell cycle process
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of cell differentiation
negative regulation of cell death
positive regulation of immune system process
regulation of cell cycle
positive regulation of developmental process
integral component of plasma membrane
regulation of apoptotic process
regulation of programmed cell death
cell development
regulation of immune system process
regulation of cell death
positive regulation of multicellular organismal process
regulation of cell differentiation