EXTL3

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). {ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:28132690, ECO:0000269|PubMed:28148688}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Exostosin
Glyco transf 64

glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
transferase activity, transferring glycosyl groups
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
polysaccharide biosynthetic process
cellular polysaccharide biosynthetic process
IRE1-mediated unfolded protein response
cellular carbohydrate biosynthetic process
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
endoplasmic reticulum unfolded protein response
aminoglycan biosynthetic process
carbohydrate biosynthetic process
cellular response to unfolded protein
cellular response to topologically incorrect protein
glycosaminoglycan metabolic process
response to unfolded protein
positive regulation of cell growth
aminoglycan metabolic process
cellular carbohydrate metabolic process
response to topologically incorrect protein
response to endoplasmic reticulum stress
protein glycosylation
macromolecule glycosylation
positive regulation of growth
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
regulation of cell growth
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
regulation of growth
endoplasmic reticulum membrane
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process