F2R [The Human Chemical-Genetic Interaction Map Project]

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======= F2R =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: F2R
  * **<color #00a2e8>Official Name</color>**: coagulation factor II thrombin receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2149|2149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25116|P25116]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=F2R&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20F2R|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of renin secretion into blood stream|
|establishment of synaptic specificity at neuromuscular junction|
|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission|
|trans-synaptic signaling by lipid, modulating synaptic transmission|
|platelet dense tubular network|
|regulation of renin secretion into blood stream|
|negative regulation of glomerular filtration|
|connective tissue replacement involved in inflammatory response wound healing|
|thrombin-activated receptor activity|
|connective tissue replacement|
|trans-synaptic signaling by endocannabinoid|
|trans-synaptic signaling by lipid|
|wound healing involved in inflammatory response|
|inflammatory response to wounding|
|platelet dense granule organization|
|thrombin-activated receptor signaling pathway|
|regulation of glomerular filtration|
|cell-cell junction maintenance|
|trans-synaptic signaling, modulating synaptic transmission|
|positive regulation of interleukin-8 secretion|
|cell junction maintenance|
|renal system process involved in regulation of blood volume|
|G-protein beta-subunit binding|
|regulation of interleukin-8 secretion|
|G-protein alpha-subunit binding|
|renal system process involved in regulation of systemic arterial blood pressure|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|protein kinase C-activating G protein-coupled receptor signaling pathway|
|positive regulation of Rho protein signal transduction|
|homeostasis of number of cells within a tissue|
|positive regulation of interleukin-6 secretion|
|positive regulation of vasoconstriction|
|positive regulation of smooth muscle contraction|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|negative regulation of blood circulation|
|secretory granule organization|
|regulation of renal system process|
|regulation of collagen biosynthetic process|
|regulation of sensory perception of pain|
|regulation of sensory perception|
|regulation of collagen metabolic process|
|positive regulation of release of sequestered calcium ion into cytosol|
|neuromuscular junction development|
|regulation of endocrine process|
|positive regulation of muscle contraction|
|cellular component maintenance|
|positive regulation of interleukin-8 production|
|activation of MAPKK activity|
|positive regulation of calcium ion transport into cytosol|
|positive regulation of wound healing|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|regulation of vasoconstriction|
|regulation of smooth muscle contraction|
|positive regulation of response to wounding|
|positive regulation of Ras protein signal transduction|
|calcium ion transmembrane import into cytosol|
|regulation of interleukin-8 production|
|positive regulation of calcium ion transmembrane transport|
|positive regulation of blood circulation|
|positive regulation of small GTPase mediated signal transduction|
|calcium ion transport into cytosol|
|caveola|
|neuromuscular junction|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of interleukin-1 beta production|
|regulation of coagulation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of receptor signaling pathway via STAT|
|cytosolic calcium ion transport|
|regulation of systemic arterial blood pressure|
|regulation of interleukin-1 production|
|positive regulation of interleukin-6 production|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of calcium ion transport into cytosol|
|tissue remodeling|
|renal system process|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|late endosome|
|regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of protein secretion|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of receptor signaling pathway via STAT|
|regulation of nervous system process|
|platelet activation|
|regulation of wound healing|
|cell-cell junction organization|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|positive regulation of cytokine secretion|
|negative regulation of peptide secretion|
|regulation of tube size|
|regulation of interleukin-6 production|
|positive regulation of cation transmembrane transport|
|regulation of Rho protein signal transduction|
|negative regulation of neuron apoptotic process|
|regulation of calcium ion transmembrane transport|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of ion transmembrane transport|
|regulation of muscle contraction|
|regulation of response to wounding|
|vascular process in circulatory system|
|positive regulation of endopeptidase activity|
|negative regulation of protein transport|
|regulation of blood pressure|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of establishment of protein localization|
|tissue homeostasis|
|positive regulation of peptidase activity|
|calcium ion transmembrane transport|
|homeostasis of number of cells|
|postsynaptic membrane|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|positive regulation of ERK1 and ERK2 cascade|
|cell junction organization|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of secretion|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of muscle system process|
|regulation of cysteine-type endopeptidase activity|
|regulation of Ras protein signal transduction|
|regulation of calcium ion transport|
|calcium ion transport|
|early endosome|
|positive regulation of MAP kinase activity|
|synapse organization|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|blood coagulation|
|regulation of ERK1 and ERK2 cascade|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|vesicle organization|
|divalent inorganic cation transport|
|regulation of neuron death|
|response to lipopolysaccharide|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|regulation of small GTPase mediated signal transduction|
|positive regulation of proteolysis|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of GTPase activity|
|regulation of endopeptidase activity|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|wound healing|
|regulation of GTPase activity|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|regulation of proteolysis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|cation transport|
|regulation of cell migration|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|regulation of transferase activity|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|cell activation|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|transmembrane transport|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.92|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.86|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.82|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.79|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.7|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.7|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.71|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='F2R Expression in NALM6 Cells: 2.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>