F2R
Gene Information
- Official Symbol: F2R
- Official Name: coagulation factor II thrombin receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 2149
- UniProt: P25116
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
- UniProt Summary: High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}.
Pfam Domains GO Terms
Pfam Domains
| 7tm 1 |
GO Terms
| negative regulation of renin secretion into blood stream |
| establishment of synaptic specificity at neuromuscular junction |
| trans-synaptic signaling by endocannabinoid, modulating synaptic transmission |
| trans-synaptic signaling by lipid, modulating synaptic transmission |
| platelet dense tubular network |
| regulation of renin secretion into blood stream |
| negative regulation of glomerular filtration |
| connective tissue replacement involved in inflammatory response wound healing |
| thrombin-activated receptor activity |
| connective tissue replacement |
| trans-synaptic signaling by endocannabinoid |
| trans-synaptic signaling by lipid |
| wound healing involved in inflammatory response |
| inflammatory response to wounding |
| platelet dense granule organization |
| thrombin-activated receptor signaling pathway |
| regulation of glomerular filtration |
| cell-cell junction maintenance |
| trans-synaptic signaling, modulating synaptic transmission |
| positive regulation of interleukin-8 secretion |
| cell junction maintenance |
| renal system process involved in regulation of blood volume |
| G-protein beta-subunit binding |
| regulation of interleukin-8 secretion |
| G-protein alpha-subunit binding |
| renal system process involved in regulation of systemic arterial blood pressure |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| positive regulation of hemostasis |
| positive regulation of blood coagulation |
| positive regulation of coagulation |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| positive regulation of Rho protein signal transduction |
| homeostasis of number of cells within a tissue |
| positive regulation of interleukin-6 secretion |
| positive regulation of vasoconstriction |
| positive regulation of smooth muscle contraction |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway |
| negative regulation of blood circulation |
| secretory granule organization |
| regulation of renal system process |
| regulation of collagen biosynthetic process |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| regulation of collagen metabolic process |
| positive regulation of release of sequestered calcium ion into cytosol |
| neuromuscular junction development |
| regulation of endocrine process |
| positive regulation of muscle contraction |
| cellular component maintenance |
| positive regulation of interleukin-8 production |
| activation of MAPKK activity |
| positive regulation of calcium ion transport into cytosol |
| positive regulation of wound healing |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| regulation of vasoconstriction |
| regulation of smooth muscle contraction |
| positive regulation of response to wounding |
| positive regulation of Ras protein signal transduction |
| calcium ion transmembrane import into cytosol |
| regulation of interleukin-8 production |
| positive regulation of calcium ion transmembrane transport |
| positive regulation of blood circulation |
| positive regulation of small GTPase mediated signal transduction |
| calcium ion transport into cytosol |
| caveola |
| neuromuscular junction |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of interleukin-1 beta production |
| regulation of coagulation |
| positive regulation of receptor signaling pathway via JAK-STAT |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| positive regulation of receptor signaling pathway via STAT |
| cytosolic calcium ion transport |
| regulation of systemic arterial blood pressure |
| regulation of interleukin-1 production |
| positive regulation of interleukin-6 production |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of calcium ion transport into cytosol |
| tissue remodeling |
| renal system process |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| late endosome |
| regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of protein secretion |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of receptor signaling pathway via STAT |
| regulation of nervous system process |
| platelet activation |
| regulation of wound healing |
| cell-cell junction organization |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| positive regulation of cytokine secretion |
| negative regulation of peptide secretion |
| regulation of tube size |
| regulation of interleukin-6 production |
| positive regulation of cation transmembrane transport |
| regulation of Rho protein signal transduction |
| negative regulation of neuron apoptotic process |
| regulation of calcium ion transmembrane transport |
| positive regulation of cysteine-type endopeptidase activity |
| positive regulation of ion transmembrane transport |
| regulation of muscle contraction |
| regulation of response to wounding |
| vascular process in circulatory system |
| positive regulation of endopeptidase activity |
| negative regulation of protein transport |
| regulation of blood pressure |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| negative regulation of establishment of protein localization |
| tissue homeostasis |
| positive regulation of peptidase activity |
| calcium ion transmembrane transport |
| homeostasis of number of cells |
| postsynaptic membrane |
| positive regulation of transmembrane transport |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| positive regulation of ERK1 and ERK2 cascade |
| cell junction organization |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of secretion |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of muscle system process |
| regulation of cysteine-type endopeptidase activity |
| regulation of Ras protein signal transduction |
| regulation of calcium ion transport |
| calcium ion transport |
| early endosome |
| positive regulation of MAP kinase activity |
| synapse organization |
| positive regulation of protein secretion |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| blood coagulation |
| regulation of ERK1 and ERK2 cascade |
| coagulation |
| divalent metal ion transport |
| hemostasis |
| vesicle organization |
| divalent inorganic cation transport |
| regulation of neuron death |
| response to lipopolysaccharide |
| multicellular organismal homeostasis |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| activation of protein kinase activity |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| positive regulation of protein serine/threonine kinase activity |
| anatomical structure homeostasis |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| positive regulation of proteolysis |
| regulation of metal ion transport |
| blood circulation |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of GTPase activity |
| regulation of endopeptidase activity |
| endomembrane system organization |
| positive regulation of protein transport |
| positive regulation of secretion |
| cellular calcium ion homeostasis |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of protein secretion |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| wound healing |
| regulation of GTPase activity |
| negative regulation of transport |
| divalent inorganic cation homeostasis |
| regulation of peptide secretion |
| regulation of body fluid levels |
| inflammatory response |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cell motility |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| positive regulation of MAPK cascade |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| regulation of transmembrane transport |
| response to wounding |
| positive regulation of kinase activity |
| regulation of system process |
| cation transmembrane transport |
| cell surface |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| regulation of ion transport |
| cation homeostasis |
| regulation of protein transport |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| regulation of proteolysis |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| cation transport |
| regulation of cell migration |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| ion transmembrane transport |
| regulation of transferase activity |
| regulation of locomotion |
| Golgi apparatus |
| positive regulation of transport |
| regulation of cellular component movement |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| cell activation |
| regulation of response to external stimulus |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| transmembrane transport |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| ion transport |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lead acetate 2000μM R08 exp498 no dilution day6 | -1.92 |
| PU-H71 1μM R08 exp515 | -1.86 |
| Cannabidiol 13μM R08 exp465 | -1.82 |
| IU1-47 25μM R04 exp182 | -1.79 |
| Dimethyl-Sulfoxide 1pc R03 exp120 | -1.7 |
| ABT-702 5μM R06 exp261 | 1.7 |
| CCCP 1μM R00 exp11 | 1.71 |
| Isoniazid 100μM R08 exp494 | 1.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18344
- Expression level (log2 read counts): 2.17
Expression Distribution
F2R Expression in NALM6 Cells: 2.17
