FAM103A1

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:22099306, PubMed:27422871). Promotes the recruitment of the methyl donor, S- adenosyl-L-methionine, to RNMT (PubMed:27422871). Regulates RNMT expression by a post-transcriptional stabilizing mechanism (PubMed:22099306). Binds RNA (PubMed:22099306). {ECO:0000269|PubMed:22099306, ECO:0000269|PubMed:27422871}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
mRNA (guanine-N7-)-methyltransferase activity
mRNA cap methyltransferase complex
RNA 5-cap (guanine-N7)-methylation
RNA (guanine-N7)-methylation
mRNA cap binding complex
7-methylguanosine mRNA capping
RNA capping
7-methylguanosine RNA capping
RNA methylation
RNA modification
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
macromolecule methylation
methylation
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
RNA binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression