FAM107A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM107A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM107A
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 107 member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11170|11170]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95990|O95990]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM107A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM107A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development. {ECO:0000269|PubMed:10564580}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1151|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of long-term synaptic potentiation|
|negative regulation of focal adhesion assembly|
|negative regulation of adherens junction organization|
|negative regulation of cell junction assembly|
|actin filament polymerization|
|negative regulation of cell-matrix adhesion|
|regulation of long-term synaptic potentiation|
|actin polymerization or depolymerization|
|cellular response to glucocorticoid stimulus|
|cellular response to corticosteroid stimulus|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|negative regulation of cell-substrate adhesion|
|actin filament bundle assembly|
|actin filament bundle organization|
|regulation of adherens junction organization|
|stress fiber|
|protein polymerization|
|regulation of cell junction assembly|
|ruffle membrane|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell-matrix adhesion|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|response to glucocorticoid|
|regulation of G1/S transition of mitotic cell cycle|
|response to corticosteroid|
|regulation of cell cycle G1/S phase transition|
|cellular response to steroid hormone stimulus|
|regulation of synaptic plasticity|
|regulation of microtubule cytoskeleton organization|
|regulation of protein ubiquitination|
|regulation of cell-substrate adhesion|
|negative regulation of mitotic cell cycle phase transition|
|actin cytoskeleton|
|regulation of microtubule-based process|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|cellular response to nutrient levels|
|actin filament organization|
|cellular response to extracellular stimulus|
|actin binding|
|synapse|
|negative regulation of cell adhesion|
|regulation of protein stability|
|cognition|
|negative regulation of mitotic cell cycle|
|neuron projection|
|negative regulation of cell cycle process|
|response to steroid hormone|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|regulation of actin filament-based process|
|nuclear speck|
|regulation of mitotic cell cycle phase transition|
|focal adhesion|
|regulation of cell growth|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to lipid|
|positive regulation of cell motility|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|actin filament-based process|
|negative regulation of cell cycle|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|regulation of growth|
|regulation of cell adhesion|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|molecular function|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|cytoskeleton organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|nervous system process|
|response to endogenous stimulus|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10067
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM107A Expression in NALM6 Cells: 0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>