FAM132B [The Human Chemical-Genetic Interaction Map Project]

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======= FAM132B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ERFE
  * **<color #00a2e8>Official Name</color>**: erythroferrone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151176|151176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4G0M1|Q4G0M1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM132B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM132B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615099|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. {ECO:0000250|UniProtKB:Q6PGN1}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of fatty acid transport|
|regulation of fatty acid transport|
|positive regulation of organic acid transport|
|positive regulation of anion transport|
|regulation of organic acid transport|
|positive regulation of lipid transport|
|cellular iron ion homeostasis|
|iron ion homeostasis|
|cell|
|positive regulation of lipid localization|
|regulation of fatty acid metabolic process|
|regulation of anion transport|
|hormone activity|
|cellular transition metal ion homeostasis|
|regulation of lipid transport|
|transition metal ion homeostasis|
|regulation of lipid localization|
|regulation of cellular ketone metabolic process|
|positive regulation of ion transport|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|protein homodimerization activity|
|cellular homeostasis|
|positive regulation of transport|
|chemical homeostasis|
|extracellular space|
|homeostatic process|
|regulation of transport|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.23|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM132B Expression in NALM6 Cells: -0.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>