FAM150B

Gene Information

Official Symbol: ALKAL2
Official Name: ALK and LTK ligand 2
Aliases and Previous Symbols: N/A
Entrez ID: 285016
UniProt: Q6UX46
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation. {ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14200
Expression level (log2 read counts): -2.51

Expression Distribution

positive regulation of ERK5 cascade
regulation of ERK5 cascade
receptor signaling protein tyrosine kinase activator activity
positive regulation of protein tyrosine kinase activity
receptor tyrosine kinase binding
regulation of protein tyrosine kinase activity
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of ERK1 and ERK2 cascade
regulation of peptidyl-tyrosine phosphorylation
positive regulation of neuron projection development
regulation of ERK1 and ERK2 cascade
positive regulation of neuron differentiation
positive regulation of cell projection organization
positive regulation of neurogenesis
regulation of neuron projection development
positive regulation of protein kinase activity
positive regulation of nervous system development
positive regulation of cell development
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of MAPK cascade
regulation of protein kinase activity
regulation of neurogenesis
regulation of kinase activity
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of cellular component organization
positive regulation of protein modification process
positive regulation of developmental process