FAM161A

Entrez Summary: This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011].
UniProt Summary: Involved in ciliogenesis. {ECO:0000269|PubMed:22940612}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

astral microtubule
mitotic spindle pole
spindle microtubule
photoreceptor connecting cilium
positive regulation of protein acetylation
photoreceptor inner segment
regulation of protein acetylation
mitotic spindle
ciliary basal body
visual perception
sensory perception of light stimulus
microtubule binding
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
centrosome
organelle assembly
sensory perception
identical protein binding
plasma membrane bounded cell projection organization
cell projection organization
positive regulation of protein modification process
nervous system process
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
regulation of protein modification process
system process