FAM53B

Entrez Summary: N/A
UniProt Summary: Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. {ECO:0000269|PubMed:25183871}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein import into nucleus
import into nucleus
protein import
positive regulation of canonical Wnt signaling pathway
protein localization to nucleus
positive regulation of Wnt signaling pathway
nucleocytoplasmic transport
nuclear transport
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
cell surface receptor signaling pathway involved in cell-cell signaling
establishment of protein localization to organelle
protein localization to organelle
intracellular protein transport
cell-cell signaling
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
establishment of localization in cell
nitrogen compound transport