FAM96B

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. {ECO:0000269|PubMed:20797633}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.33
TRAIL 50ng/ml R00 exp36	-1.93
Deferoxamine 11μM R07 exp350	-1.9
ONC212 0.15μM R08 exp513	-1.84
MLN-4924 0.2μM R00 exp21	-1.83
WYE-354 6μM R02 exp90	-1.74
TIC10 10μM R08 exp532	-1.72
NFN1 1μM R03 exp100	1.84
Hypoxia 5%O2 R04 exp191	3.38

Global Fraction of Cell Lines Where Essential: 687/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	26/28
blood	23/28
bone	26/26
breast	28/33
central nervous system	52/56
cervix	4/4
colorectal	13/17
esophagus	12/13
fibroblast	1/1
gastric	13/16
kidney	20/21
liver	20/20
lung	72/75
lymphocyte	14/16
ovary	25/26
pancreas	23/24
peripheral nervous system	14/16
plasma cell	11/15
prostate	0/1
skin	23/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

Gene	Correlation
GLRX3	0.481
MMS19	0.434

CIA complex
protein maturation by [4Fe-4S] cluster transfer
MMXD complex
protein maturation by iron-sulfur cluster transfer
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
spindle
cofactor biosynthetic process
protein maturation
chromosome segregation
sulfur compound metabolic process
cofactor metabolic process
gene expression