FAM98A [The Human Chemical-Genetic Interaction Map Project]

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======= FAM98A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FAM98A
  * **<color #00a2e8>Official Name</color>**: family with sequence similarity 98 member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25940|25940]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NCA5|Q8NCA5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FAM98A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FAM98A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620904|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436). {ECO:0000250|UniProtKB:Q3TJZ6, ECO:0000269|PubMed:28040436}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2465|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-splicing ligase complex|
|protein methyltransferase activity|
|positive regulation of ruffle assembly|
|regulation of ruffle assembly|
|lysosome localization|
|positive regulation of plasma membrane bounded cell projection assembly|
|protein methylation|
|protein alkylation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|macromolecule methylation|
|methylation|
|positive regulation of cell projection organization|
|positive regulation of cellular component biogenesis|
|organelle localization|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|positive regulation of cell population proliferation|
|regulation of cellular component biogenesis|
|positive regulation of cellular component organization|
|RNA binding|
|regulation of cell population proliferation|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.72|
|[[:results:exp302|35°C R06 exp302]]|1.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.72|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.8|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.82|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.95|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FAM98A Expression in NALM6 Cells: 6.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>