FAM98A

Entrez Summary: N/A
UniProt Summary: Positively stimulates PRMT1-induced protein arginine methylation (PubMed:28040436). Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). Promotes colorectal cancer cell malignancy (PubMed:28040436). {ECO:0000250|UniProtKB:Q3TJZ6, ECO:0000269|PubMed:28040436}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

tRNA-splicing ligase complex
protein methyltransferase activity
positive regulation of ruffle assembly
regulation of ruffle assembly
lysosome localization
positive regulation of plasma membrane bounded cell projection assembly
protein methylation
protein alkylation
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
macromolecule methylation
methylation
positive regulation of cell projection organization
positive regulation of cellular component biogenesis
organelle localization
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
positive regulation of cell population proliferation
regulation of cellular component biogenesis
positive regulation of cellular component organization
RNA binding
regulation of cell population proliferation
positive regulation of gene expression