FARP2 [The Human Chemical-Genetic Interaction Map Project]

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======= FARP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FARP2
  * **<color #00a2e8>Official Name</color>**: FERM, ARH/RhoGEF and pleckstrin domain protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9855|9855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94887|O94887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FARP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FARP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617586|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM N|
|RhoGEF|
|FERM M|
|FERM C|
|PH|
|FA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|podosome assembly|
|neuron remodeling|
|regulation of integrin activation|
|Rac guanyl-nucleotide exchange factor activity|
|Rac protein signal transduction|
|semaphorin-plexin signaling pathway|
|neuron maturation|
|osteoclast differentiation|
|actin cytoskeleton reorganization|
|Rho guanyl-nucleotide exchange factor activity|
|molting cycle process|
|hair cycle process|
|cytoskeletal protein binding|
|molting cycle|
|hair cycle|
|myeloid leukocyte differentiation|
|anatomical structure maturation|
|regulation of Rho protein signal transduction|
|cell maturation|
|myeloid cell differentiation|
|developmental maturation|
|regulation of Ras protein signal transduction|
|Ras protein signal transduction|
|small GTPase mediated signal transduction|
|leukocyte differentiation|
|regulation of small GTPase mediated signal transduction|
|cytoskeleton|
|regulation of protein complex assembly|
|actin cytoskeleton organization|
|hemopoiesis|
|actin filament-based process|
|hematopoietic or lymphoid organ development|
|immune system development|
|organelle assembly|
|neuron development|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|neuron differentiation|
|cytoskeleton organization|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.01|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5488
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FARP2 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>