FARP2

Entrez Summary: N/A
UniProt Summary: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.015μM R05 exp208	-2.01
Doxycycline 10μM R00 exp18	1.73

podosome assembly
neuron remodeling
regulation of integrin activation
Rac guanyl-nucleotide exchange factor activity
Rac protein signal transduction
semaphorin-plexin signaling pathway
neuron maturation
osteoclast differentiation
actin cytoskeleton reorganization
Rho guanyl-nucleotide exchange factor activity
molting cycle process
hair cycle process
cytoskeletal protein binding
molting cycle
hair cycle
myeloid leukocyte differentiation
anatomical structure maturation
regulation of Rho protein signal transduction
cell maturation
myeloid cell differentiation
developmental maturation
regulation of Ras protein signal transduction
Ras protein signal transduction
small GTPase mediated signal transduction
leukocyte differentiation
regulation of small GTPase mediated signal transduction
cytoskeleton
regulation of protein complex assembly
actin cytoskeleton organization
hemopoiesis
actin filament-based process
hematopoietic or lymphoid organ development
immune system development
organelle assembly
neuron development
cell adhesion
biological adhesion
regulation of cellular component biogenesis
neuron differentiation
cytoskeleton organization