FARSB [The Human Chemical-Genetic Interaction Map Project]

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======= FARSB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FARSB
  * **<color #00a2e8>Official Name</color>**: phenylalanyl-tRNA synthetase subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10056|10056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSD9|Q9NSD9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FARSB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FARSB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|B5|
|B3 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phenylalanine-tRNA ligase complex|
|phenylalanyl-tRNA aminoacylation|
|phenylalanine-tRNA ligase activity|
|protein heterotetramerization|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|protein heterooligomerization|
|protein tetramerization|
|tRNA metabolic process|
|magnesium ion binding|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|protein complex oligomerization|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|RNA binding|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-3.11|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-2.2|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.17|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.15|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.11|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.94|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.93|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.9|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.85|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.77|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.574|
|[[:human genes:z:znf259|ZNF259]]|0.436|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 342
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FARSB Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>