FBP1

Gene Information

Official Symbol: FBP1
Official Name: fructose-bisphosphatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 2203
UniProt: P09467
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8943
Expression level (log2 read counts): -7.68

Expression Distribution

fructose 1,6-bisphosphate 1-phosphatase activity
sucrose biosynthetic process
sucrose metabolic process
disaccharide biosynthetic process
cellular response to magnesium ion
fructose 6-phosphate metabolic process
fructose 1,6-bisphosphate metabolic process
disaccharide metabolic process
AMP binding
negative regulation of glycolytic process
monosaccharide binding
fructose metabolic process
oligosaccharide biosynthetic process
negative regulation of purine nucleotide metabolic process
negative regulation of nucleotide metabolic process
response to magnesium ion
negative regulation of ATP metabolic process
negative regulation of cellular carbohydrate metabolic process
gluconeogenesis
regulation of gluconeogenesis
hexose biosynthetic process
negative regulation of carbohydrate metabolic process
oligosaccharide metabolic process
negative regulation of Ras protein signal transduction
monosaccharide biosynthetic process
cellular carbohydrate biosynthetic process
negative regulation of small GTPase mediated signal transduction
RNA polymerase II transcription factor binding
regulation of glycolytic process
regulation of carbohydrate catabolic process
negative regulation of small molecule metabolic process
protein homotetramerization
regulation of carbohydrate biosynthetic process
glucose metabolic process
regulation of glucose metabolic process
regulation of purine nucleotide metabolic process
regulation of nucleotide metabolic process
regulation of ATP metabolic process
carbohydrate biosynthetic process
regulation of cellular carbohydrate metabolic process