FBXO45 [The Human Chemical-Genetic Interaction Map Project]

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======= FBXO45 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FBXO45
  * **<color #00a2e8>Official Name</color>**: F-box protein 45
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=200933|200933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0C2W1|P0C2W1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FBXO45&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FBXO45|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. {ECO:0000250, ECO:0000269|PubMed:19581926}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|F-box|
|F-box-like|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synapse assembly involved in innervation|
|anterior commissure morphogenesis|
|corticospinal tract morphogenesis|
|cerebral cortex tangential migration|
|presynaptic cytosol|
|postsynaptic cytosol|
|central nervous system projection neuron axonogenesis|
|innervation|
|cerebral cortex radially oriented cell migration|
|central nervous system neuron axonogenesis|
|cerebral cortex cell migration|
|telencephalon cell migration|
|forebrain cell migration|
|SCF ubiquitin ligase complex|
|presynaptic membrane|
|nerve development|
|central nervous system neuron development|
|synapse assembly|
|cerebral cortex development|
|neuron migration|
|pallium development|
|central nervous system neuron differentiation|
|postsynaptic membrane|
|postsynaptic density|
|telencephalon development|
|synapse|
|synapse organization|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|glutamatergic synapse|
|proteasomal protein catabolic process|
|axonogenesis|
|forebrain development|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell junction|
|cell morphogenesis involved in differentiation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|cell morphogenesis|
|brain development|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|head development|
|neuron development|
|cellular component morphogenesis|
|cellular macromolecule catabolic process|
|cell migration|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|proteolysis|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11702
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FBXO45 Expression in NALM6 Cells: 5.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>