FBXO45

Entrez Summary: N/A
UniProt Summary: Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. {ECO:0000250, ECO:0000269|PubMed:19581926}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

synapse assembly involved in innervation
anterior commissure morphogenesis
corticospinal tract morphogenesis
cerebral cortex tangential migration
presynaptic cytosol
postsynaptic cytosol
central nervous system projection neuron axonogenesis
innervation
cerebral cortex radially oriented cell migration
central nervous system neuron axonogenesis
cerebral cortex cell migration
telencephalon cell migration
forebrain cell migration
SCF ubiquitin ligase complex
presynaptic membrane
nerve development
central nervous system neuron development
synapse assembly
cerebral cortex development
neuron migration
pallium development
central nervous system neuron differentiation
postsynaptic membrane
postsynaptic density
telencephalon development
synapse
synapse organization
proteasome-mediated ubiquitin-dependent protein catabolic process
glutamatergic synapse
proteasomal protein catabolic process
axonogenesis
forebrain development
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process