FCGR1A

Gene Information

Official Symbol: FCGR1A
Official Name: Fc fragment of IgG receptor Ia
Aliases and Previous Symbols: N/A
Entrez ID: 2209
UniProt: P12314
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008].
UniProt Summary: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6373
Expression level (log2 read counts): -6.6

Expression Distribution

IgG binding
clathrin-coated endocytic vesicle membrane
positive regulation of protein tyrosine kinase activity
interferon-gamma-mediated signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of protein tyrosine kinase activity
antigen processing and presentation of peptide antigen via MHC class I
phagocytosis, engulfment
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
plasma membrane invagination
Fc-gamma receptor signaling pathway
membrane invagination
early endosome membrane
cellular response to interferon-gamma
antigen processing and presentation of exogenous peptide antigen
response to interferon-gamma
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
positive regulation of peptidyl-tyrosine phosphorylation
antigen processing and presentation
receptor-mediated endocytosis
Fc receptor signaling pathway
regulation of peptidyl-tyrosine phosphorylation
phagocytosis
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
positive regulation of protein kinase activity
endocytosis
immune response-activating signal transduction
positive regulation of kinase activity
immune response-regulating signaling pathway
activation of immune response
positive regulation of transferase activity
cytokine-mediated signaling pathway
import into cell
innate immune response
regulation of protein kinase activity