FGD2

Entrez Summary: The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016].
UniProt Summary: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol phosphate binding
filopodium assembly
small GTPase binding
Rho guanyl-nucleotide exchange factor activity
positive regulation of JUN kinase activity
regulation of JUN kinase activity
ruffle
ruffle membrane
guanyl-nucleotide exchange factor activity
positive regulation of JNK cascade
regulation of Rho protein signal transduction
early endosome membrane
regulation of cell shape
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
lamellipodium
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
regulation of Ras protein signal transduction
positive regulation of MAP kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of small GTPase mediated signal transduction
cytoskeleton
plasma membrane bounded cell projection assembly
cell projection assembly
regulation of GTPase activity
regulation of cell morphogenesis
actin cytoskeleton organization
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
actin filament-based process
positive regulation of kinase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
positive regulation of cell death
regulation of cellular response to stress