FGF18 [The Human Chemical-Genetic Interaction Map Project]

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======= FGF18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FGF18
  * **<color #00a2e8>Official Name</color>**: fibroblast growth factor 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8817|8817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76093|O76093]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FGF18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FGF18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. {ECO:0000269|PubMed:16597617}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type 2 fibroblast growth factor receptor binding|
|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|
|positive regulation of cell chemotaxis to fibroblast growth factor|
|type 1 fibroblast growth factor receptor binding|
|intramembranous ossification|
|direct ossification|
|regulation of cell chemotaxis to fibroblast growth factor|
|regulation of endothelial cell chemotaxis to fibroblast growth factor|
|positive regulation of endothelial cell chemotaxis|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of chondrocyte differentiation|
|regulation of endothelial cell chemotaxis|
|endochondral ossification|
|replacement ossification|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of cartilage development|
|chondrocyte development|
|regulation of chondrocyte differentiation|
|positive regulation of blood vessel endothelial cell migration|
|regulation of sprouting angiogenesis|
|regulation of cartilage development|
|endochondral bone morphogenesis|
|fibroblast growth factor receptor signaling pathway|
|chondrocyte differentiation|
|regulation of blood vessel endothelial cell migration|
|positive regulation of endothelial cell migration|
|cellular response to fibroblast growth factor stimulus|
|bone morphogenesis|
|response to fibroblast growth factor|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|growth factor activity|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|lung development|
|cartilage development|
|respiratory tube development|
|positive regulation of vasculature development|
|respiratory system development|
|bone development|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|regulation of protein kinase B signaling|
|regulation of epithelial cell migration|
|connective tissue development|
|skeletal system morphogenesis|
|positive regulation of MAP kinase activity|
|ossification|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of ERK1 and ERK2 cascade|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|blood vessel morphogenesis|
|blood vessel development|
|skeletal system development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|tube morphogenesis|
|positive regulation of transferase activity|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|nucleolus|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FGF18 Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>