FGF18

Gene Information

Official Symbol: FGF18
Official Name: fibroblast growth factor 18
Aliases and Previous Symbols: N/A
Entrez ID: 8817
UniProt: O76093
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008].
UniProt Summary: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. {ECO:0000269|PubMed:16597617}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12001
Expression level (log2 read counts): 0.0

Expression Distribution

type 2 fibroblast growth factor receptor binding
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of cell chemotaxis to fibroblast growth factor
type 1 fibroblast growth factor receptor binding
intramembranous ossification
direct ossification
regulation of cell chemotaxis to fibroblast growth factor
regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of endothelial cell chemotaxis
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of chondrocyte differentiation
regulation of endothelial cell chemotaxis
endochondral ossification
replacement ossification
regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of cartilage development
chondrocyte development
regulation of chondrocyte differentiation
positive regulation of blood vessel endothelial cell migration
regulation of sprouting angiogenesis
regulation of cartilage development
endochondral bone morphogenesis
fibroblast growth factor receptor signaling pathway
chondrocyte differentiation
regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell migration
cellular response to fibroblast growth factor stimulus
bone morphogenesis
response to fibroblast growth factor
regulation of endothelial cell proliferation
positive regulation of chemotaxis
positive regulation of epithelial cell migration
regulation of endothelial cell migration
growth factor activity
positive regulation of angiogenesis
positive regulation of protein kinase B signaling
lung development
cartilage development
respiratory tube development
positive regulation of vasculature development