FGF2

Gene Information

Official Symbol: FGF2
Official Name: fibroblast growth factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 2247
UniProt: P09038
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18088
Expression level (log2 read counts): 1.3

Expression Distribution

growth factor dependent regulation of skeletal muscle satellite cell proliferation
positive regulation of cell fate specification
receptor-receptor interaction
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of cell chemotaxis to fibroblast growth factor
chondroblast differentiation
paracrine signaling
regulation of endothelial cell chemotaxis to fibroblast growth factor
regulation of cell chemotaxis to fibroblast growth factor
negative regulation of fibroblast migration
positive regulation of cell fate commitment
regulation of cell fate specification
regulation of skeletal muscle satellite cell proliferation
regulation of skeletal muscle cell proliferation
positive regulation of vascular endothelial cell proliferation
positive regulation of endothelial cell chemotaxis
hyaluronan catabolic process
regulation of vascular endothelial cell proliferation
regulation of endothelial cell chemotaxis
cell migration involved in sprouting angiogenesis
positive regulation of cell migration involved in sprouting angiogenesis
fibroblast growth factor receptor binding
positive regulation of cardiac muscle cell proliferation
inositol phosphate biosynthetic process
regulation of cell fate commitment
regulation of fibroblast migration
blood vessel endothelial cell migration
hyaluronan metabolic process
negative regulation of blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of vascular smooth muscle cell proliferation
positive regulation of cardiac muscle tissue growth
chemoattractant activity
positive regulation of lipid kinase activity
positive regulation of heart growth
regulation of cell migration involved in sprouting angiogenesis
positive regulation of sprouting angiogenesis
regulation of cardiac muscle cell proliferation
positive regulation of phospholipase C activity
positive regulation of cardiac muscle tissue development