FGFR2
Gene Information
- Official Symbol: FGFR2
- Official Name: fibroblast growth factor receptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2263
- UniProt: P21802
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| I-set |
| Pkinase |
| ig |
| Pkinase Tyr |
GO Terms
| fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow |
| fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell |
| fibroblast growth factor receptor signaling pathway involved in hemopoiesis |
| squamous basal epithelial stem cell differentiation involved in prostate gland acinus development |
| fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development |
| mammary gland bud formation |
| branch elongation involved in salivary gland morphogenesis |
| mesenchymal cell differentiation involved in lung development |
| fibroblast growth factor receptor signaling pathway involved in mammary gland specification |
| prostate epithelial cord elongation |
| mammary gland bud morphogenesis |
| mesenchymal cell proliferation involved in lung development |
| ventricular zone neuroblast division |
| mammary gland specification |
| prostate gland morphogenetic growth |
| orbitofrontal cortex development |
| epithelial cell proliferation involved in salivary gland morphogenesis |
| negative regulation of apoptotic process in bone marrow cell |
| positive regulation of epithelial cell proliferation involved in lung morphogenesis |
| branching morphogenesis of a nerve |
| fibroblast growth factor-activated receptor activity |
| regulation of apoptotic process in bone marrow cell |
| prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
| prostate glandular acinus morphogenesis |
| forebrain ventricular zone progenitor cell division |
| pyramidal neuron development |
| regulation of epithelial cell proliferation involved in lung morphogenesis |
| positive regulation of cell proliferation in bone marrow |
| lung lobe morphogenesis |
| regulation of cell proliferation in bone marrow |
| mammary gland formation |
| bud elongation involved in lung branching |
| lung lobe development |
| lacrimal gland development |
| morphogenesis of an epithelial bud |
| pyramidal neuron differentiation |
| otic vesicle formation |
| lung-associated mesenchyme development |
| otic vesicle morphogenesis |
| forebrain neuroblast division |
| lateral sprouting from an epithelium |
| branching involved in prostate gland morphogenesis |
| membranous septum morphogenesis |
| prostate gland growth |
| prostate glandular acinus development |
| limb bud formation |
| epithelial cell differentiation involved in prostate gland development |
| branching involved in labyrinthine layer morphogenesis |
| otic vesicle development |
| neuroblast division |
| specification of animal organ identity |
| neuronal stem cell division |
| mesenchymal cell proliferation |
| branching involved in salivary gland morphogenesis |
| branch elongation of an epithelium |
| embryonic digestive tract morphogenesis |
| morphogenesis of an epithelial fold |
| labyrinthine layer morphogenesis |
| prostate gland epithelium morphogenesis |
| regulation of osteoblast proliferation |
| somatic stem cell division |
| fibroblast growth factor binding |
| prostate gland morphogenesis |
| positive regulation of cardiac muscle cell proliferation |
| hair follicle morphogenesis |
| positive regulation of mesenchymal cell proliferation |
| epithelial tube branching involved in lung morphogenesis |
| embryonic placenta morphogenesis |
| mesodermal cell differentiation |
| axis elongation |
| outflow tract septum morphogenesis |
| cell proliferation in forebrain |
| salivary gland morphogenesis |
| epidermis morphogenesis |
| mammary gland duct morphogenesis |
| regulation of smooth muscle cell differentiation |
| forebrain neuron development |
| excitatory synapse |
| neuroblast proliferation |
| salivary gland development |
| regulation of mesenchymal cell proliferation |
| positive regulation of cardiac muscle tissue growth |
| stem cell division |
| animal organ formation |
| embryonic digestive tract development |
| positive regulation of heart growth |
| glandular epithelial cell differentiation |
| regulation of cardiac muscle cell proliferation |
| prostate gland development |
| lung alveolus development |
| ventricular septum morphogenesis |
| endochondral bone growth |
| mammary gland morphogenesis |
| exocrine system development |
| lung morphogenesis |
| positive regulation of cardiac muscle tissue development |
| bone growth |
| embryonic cranial skeleton morphogenesis |
| labyrinthine layer development |
| ventricular cardiac muscle tissue morphogenesis |
| bone mineralization |
| positive regulation of organ growth |
| digestive tract morphogenesis |
| forebrain neuron differentiation |
| stem cell proliferation |
| transmembrane receptor protein tyrosine kinase activity |
| ventricular cardiac muscle tissue development |
| regulation of morphogenesis of a branching structure |
| regulation of cardiac muscle tissue growth |
| mammary gland epithelium development |
| positive regulation of phospholipase activity |
| embryonic pattern specification |
| regulation of heart growth |
| cranial skeletal system development |
| forebrain generation of neurons |
| mesoderm formation |
| cardiac muscle tissue morphogenesis |
| mesoderm morphogenesis |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle organ development |
| cellular response to retinoic acid |
| positive regulation of muscle tissue development |
| epithelial to mesenchymal transition |
| positive regulation of lipase activity |
| regulation of phospholipase activity |
| hair follicle development |
| ventricular septum development |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| skin epidermis development |
| cardiac ventricle morphogenesis |
| neural precursor cell proliferation |
| hair cycle process |
| molting cycle process |
| regulation of smoothened signaling pathway |
| regulation of cardiac muscle tissue development |
| muscle tissue morphogenesis |
| central nervous system neuron development |
| fibroblast growth factor receptor signaling pathway |
| positive regulation of animal organ morphogenesis |
| positive regulation of smooth muscle cell proliferation |
| midbrain development |
| ureteric bud development |
| epithelial cell proliferation |
| mesonephric tubule development |
| positive regulation of cell division |
| muscle organ morphogenesis |
| embryonic placenta development |
| mesonephric epithelium development |
| protein tyrosine kinase activity |
| post-embryonic development |
| mesonephros development |
| hair cycle |
| molting cycle |
| biomineral tissue development |
| biomineralization |
| regulation of organ growth |
| embryonic skeletal system morphogenesis |
| columnar/cuboidal epithelial cell differentiation |
| organ growth |
| regulation of lipase activity |
| inner ear morphogenesis |
| gland morphogenesis |
| response to retinoic acid |
| cellular response to fibroblast growth factor stimulus |
| limbic system development |
| cardiac septum development |
| formation of primary germ layer |
| regulation of osteoblast differentiation |
| bone morphogenesis |
| developmental growth involved in morphogenesis |
| response to fibroblast growth factor |
| ear morphogenesis |
| odontogenesis |
| mesoderm development |
| negative regulation of epithelial cell proliferation |
| cardiac chamber morphogenesis |
| response to ethanol |
| embryonic skeletal system development |
| cardiac ventricle development |
| mammary gland development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| digestive tract development |
| epithelial tube formation |
| regulation of striated muscle tissue development |
| regulation of smooth muscle cell proliferation |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| cell cortex |
| digestive system development |
| peptidyl-tyrosine phosphorylation |
| positive regulation of canonical Wnt signaling pathway |
| morphogenesis of embryonic epithelium |
| peptidyl-tyrosine modification |
| tube formation |
| limb morphogenesis |
| appendage morphogenesis |
| placenta development |
| regulation of muscle cell differentiation |
| cellular response to transforming growth factor beta stimulus |
| mesenchymal cell differentiation |
| stem cell differentiation |
| gastrulation |
| morphogenesis of a branching epithelium |
| cardiac muscle tissue development |
| response to transforming growth factor beta |
| positive regulation of protein kinase B signaling |
| regulation of cell division |
| morphogenesis of a branching structure |
| lung development |
| cardiac chamber development |
| heparin binding |
| positive regulation of developmental growth |
| respiratory tube development |
| positive regulation of Wnt signaling pathway |
| central nervous system neuron differentiation |
| limb development |
| appendage development |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| protein autophosphorylation |
| inner ear development |
| respiratory system development |
| bone development |
| receptor complex |
| cellular response to acid chemical |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of protein kinase B signaling |
| ear development |
| mesenchyme development |
| response to alcohol |
| skeletal system morphogenesis |
| cell fate commitment |
| heart morphogenesis |
| cytoplasmic vesicle |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of growth |
| ossification |
| kidney development |
| regulation of canonical Wnt signaling pathway |
| striated muscle tissue development |
| renal system development |
| embryonic organ morphogenesis |
| regulation of ERK1 and ERK2 cascade |
| muscle organ development |
| muscle tissue development |
| response to antibiotic |
| epithelial tube morphogenesis |
| response to lipopolysaccharide |
| angiogenesis |
| urogenital system development |
| response to molecule of bacterial origin |
| regulation of developmental growth |
| regionalization |
| regulation of epithelial cell proliferation |
| response to acid chemical |
| regulation of Wnt signaling pathway |
| collagen-containing extracellular matrix |
| MAPK cascade |
| axonogenesis |
| in utero embryonic development |
| positive regulation of cell cycle |
| skin development |
| forebrain development |
| developmental growth |
| growth |
| signal transduction by protein phosphorylation |
| blood vessel morphogenesis |
| axon development |
| gland development |
| epidermis development |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| muscle structure development |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| cell division |
| skeletal system development |
| cellular response to growth factor stimulus |
| response to toxic substance |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| response to growth factor |
| positive regulation of MAPK cascade |
| sensory organ development |
| cell population proliferation |
| hemopoiesis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| hematopoietic or lymphoid organ development |
| cell surface |
| chordate embryonic development |
| immune system development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| intracellular membrane-bounded organelle |
| response to bacterium |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| head development |
| neuron development |
| cellular component morphogenesis |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| apoptotic process |
| animal organ morphogenesis |
| protein phosphorylation |
| embryo development |
| central nervous system development |
| Golgi apparatus |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell death |
| epithelium development |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 2/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13827
- Expression level (log2 read counts): 2.09
Expression Distribution
FGFR2 Expression in NALM6 Cells: 2.09
