FKBP8

Entrez Summary: N/A
UniProt Summary: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.125μM on day4 R07 exp410	-3.28
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-3.17
THZ531 0.11μM R07 exp409	-2.98
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.57
THZ531 0.225μM R08 exp444	-1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dorsal/ventral neural tube patterning
positive regulation of BMP signaling pathway
disordered domain specific binding
neural tube patterning
peptidyl-prolyl cis-trans isomerase activity
protein peptidyl-prolyl isomerization
peptidyl-proline modification
smoothened signaling pathway
dorsal/ventral pattern formation
multicellular organism growth
cell fate specification
regulation of BMP signaling pathway
mitochondrial membrane
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
integral component of endoplasmic reticulum membrane
neural tube development
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cell fate commitment
regulation of cellular response to growth factor stimulus
camera-type eye development
regionalization
eye development
visual system development
sensory system development
developmental growth
growth
negative regulation of protein phosphorylation
pattern specification process
negative regulation of phosphorylation
sensory organ development
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
protein-containing complex
chordate embryonic development
embryo development ending in birth or egg hatching
viral process
symbiotic process
interspecies interaction between organisms
tube development