FKTN [The Human Chemical-Genetic Interaction Map Project]

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======= FKTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FKTN
  * **<color #00a2e8>Official Name</color>**: fukutin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2218|2218]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75072|O75072]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FKTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FKTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development. {ECO:0000269|PubMed:25279699}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LicD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein glycosylation|
|protein O-linked mannosylation|
|protein mannosylation|
|negative regulation of JNK cascade|
|mannosylation|
|regulation of glycoprotein biosynthetic process|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|regulation of glycoprotein metabolic process|
|transferase activity|
|integral component of Golgi membrane|
|cis-Golgi network|
|protein O-linked glycosylation|
|negative regulation of MAPK cascade|
|regulation of JNK cascade|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|muscle organ development|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|muscle structure development|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|carbohydrate derivative biosynthetic process|
|negative regulation of cell population proliferation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|Golgi apparatus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.2|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.95|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.84|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FKTN Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>