FKTN

Entrez Summary: The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development. {ECO:0000269|PubMed:25279699}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of protein glycosylation
protein O-linked mannosylation
protein mannosylation
negative regulation of JNK cascade
mannosylation
regulation of glycoprotein biosynthetic process
negative regulation of stress-activated protein kinase signaling cascade
negative regulation of stress-activated MAPK cascade
regulation of glycoprotein metabolic process
transferase activity
integral component of Golgi membrane
cis-Golgi network
protein O-linked glycosylation
negative regulation of MAPK cascade
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein glycosylation
macromolecule glycosylation
glycosylation
muscle organ development
glycoprotein biosynthetic process
glycoprotein metabolic process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
muscle structure development
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
carbohydrate derivative biosynthetic process
negative regulation of cell population proliferation
regulation of cellular response to stress
regulation of MAPK cascade
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of signal transduction