FLNB [The Human Chemical-Genetic Interaction Map Project]

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======= FLNB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLNB
  * **<color #00a2e8>Official Name</color>**: filamin B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2317|2317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75369|O75369]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLNB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLNB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603381|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filamin|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoskeletal anchoring at plasma membrane|
|keratinocyte development|
|epithelial cell morphogenesis|
|brush border|
|phagocytic vesicle|
|stress fiber|
|maintenance of protein location in cell|
|maintenance of location in cell|
|maintenance of protein location|
|skeletal muscle tissue development|
|Z disc|
|skeletal muscle organ development|
|cell cortex|
|cellular response to interferon-gamma|
|maintenance of location|
|response to interferon-gamma|
|epithelial cell development|
|actin cytoskeleton|
|actin binding|
|keratinocyte differentiation|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|cadherin binding|
|epidermal cell differentiation|
|neuron projection|
|neuronal cell body|
|skin development|
|epidermis development|
|focal adhesion|
|muscle structure development|
|actin cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|epithelial cell differentiation|
|cell morphogenesis|
|innate immune response|
|cellular component morphogenesis|
|defense response to other organism|
|cellular response to cytokine stimulus|
|identical protein binding|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|cellular protein localization|
|cellular macromolecule localization|
|cell development|
|tissue development|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6960
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLNB Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>