FLNB

Entrez Summary: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Filamin
CH

cytoskeletal anchoring at plasma membrane
keratinocyte development
epithelial cell morphogenesis
brush border
phagocytic vesicle
stress fiber
maintenance of protein location in cell
maintenance of location in cell
maintenance of protein location
skeletal muscle tissue development
Z disc
skeletal muscle organ development
cell cortex
cellular response to interferon-gamma
maintenance of location
response to interferon-gamma
epithelial cell development
actin cytoskeleton
actin binding
keratinocyte differentiation
striated muscle tissue development
muscle organ development
muscle tissue development
cadherin binding
epidermal cell differentiation
neuron projection
neuronal cell body
skin development
epidermis development
focal adhesion
muscle structure development
actin cytoskeleton organization
cell morphogenesis involved in differentiation
actin filament-based process
epithelial cell differentiation
cell morphogenesis
innate immune response
cellular component morphogenesis
defense response to other organism
cellular response to cytokine stimulus