FLT3LG [The Human Chemical-Genetic Interaction Map Project]

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======= FLT3LG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FLT3LG
  * **<color #00a2e8>Official Name</color>**: fms related receptor tyrosine kinase 3 ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2323|2323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49771|P49771]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FLT3LG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FLT3LG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600007|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Flt3 lig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of osteoclast proliferation|
|intrinsic component of external side of plasma membrane|
|negative regulation of apoptotic process in bone marrow cell|
|regulation of osteoclast proliferation|
|regulation of apoptotic process in bone marrow cell|
|regulation of myeloid dendritic cell activation|
|positive regulation of natural killer cell proliferation|
|regulation of cell proliferation in bone marrow|
|positive regulation of cell proliferation in bone marrow|
|positive regulation of natural killer cell differentiation|
|regulation of natural killer cell proliferation|
|regulation of natural killer cell differentiation|
|positive regulation of myoblast fusion|
|positive regulation of natural killer cell activation|
|embryonic hemopoiesis|
|regulation of myoblast fusion|
|positive regulation of myoblast differentiation|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|homeostasis of number of cells within a tissue|
|regulation of natural killer cell activation|
|positive regulation of myotube differentiation|
|regulation of myoblast differentiation|
|regulation of myotube differentiation|
|receptor tyrosine kinase binding|
|positive regulation of striated muscle cell differentiation|
|positive regulation of muscle cell differentiation|
|positive regulation of lymphocyte differentiation|
|regulation of striated muscle cell differentiation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of leukocyte differentiation|
|regulation of muscle cell differentiation|
|regulation of lymphocyte differentiation|
|cytokine activity|
|positive regulation of hemopoiesis|
|tissue homeostasis|
|homeostasis of number of cells|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|lymphocyte differentiation|
|regulation of leukocyte differentiation|
|multicellular organismal homeostasis|
|leukocyte differentiation|
|signaling receptor binding|
|anatomical structure homeostasis|
|positive regulation of lymphocyte activation|
|MAPK cascade|
|positive regulation of cell cycle|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|embryonic organ development|
|regulation of hemopoiesis|
|regulation of lymphocyte activation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|cytokine-mediated signaling pathway|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|leukocyte activation|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|phosphorylation|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.85|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.9|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7189
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FLT3LG Expression in NALM6 Cells: 3.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>