FLT3LG
Gene Information
- Official Symbol: FLT3LG
- Official Name: fms related receptor tyrosine kinase 3 ligand
- Aliases and Previous Symbols: N/A
- Entrez ID: 2323
- UniProt: P49771
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
Pfam Domains GO Terms
Pfam Domains
| Flt3 lig |
GO Terms
| positive regulation of osteoclast proliferation |
| intrinsic component of external side of plasma membrane |
| negative regulation of apoptotic process in bone marrow cell |
| regulation of osteoclast proliferation |
| regulation of apoptotic process in bone marrow cell |
| regulation of myeloid dendritic cell activation |
| positive regulation of natural killer cell proliferation |
| regulation of cell proliferation in bone marrow |
| positive regulation of cell proliferation in bone marrow |
| positive regulation of natural killer cell differentiation |
| regulation of natural killer cell proliferation |
| regulation of natural killer cell differentiation |
| positive regulation of myoblast fusion |
| positive regulation of natural killer cell activation |
| embryonic hemopoiesis |
| regulation of myoblast fusion |
| positive regulation of myoblast differentiation |
| positive regulation of syncytium formation by plasma membrane fusion |
| regulation of syncytium formation by plasma membrane fusion |
| homeostasis of number of cells within a tissue |
| regulation of natural killer cell activation |
| positive regulation of myotube differentiation |
| regulation of myoblast differentiation |
| regulation of myotube differentiation |
| receptor tyrosine kinase binding |
| positive regulation of striated muscle cell differentiation |
| positive regulation of muscle cell differentiation |
| positive regulation of lymphocyte differentiation |
| regulation of striated muscle cell differentiation |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| positive regulation of leukocyte differentiation |
| regulation of muscle cell differentiation |
| regulation of lymphocyte differentiation |
| cytokine activity |
| positive regulation of hemopoiesis |
| tissue homeostasis |
| homeostasis of number of cells |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| lymphocyte differentiation |
| regulation of leukocyte differentiation |
| multicellular organismal homeostasis |
| leukocyte differentiation |
| signaling receptor binding |
| anatomical structure homeostasis |
| positive regulation of lymphocyte activation |
| MAPK cascade |
| positive regulation of cell cycle |
| lymphocyte activation |
| signal transduction by protein phosphorylation |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| embryonic organ development |
| regulation of hemopoiesis |
| regulation of lymphocyte activation |
| hemopoiesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cell surface |
| regulation of cell activation |
| immune system development |
| cytokine-mediated signaling pathway |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| leukocyte activation |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| negative regulation of cell death |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Clomiphene 4.4μM R02 exp68 | 1.85 |
| TRAIL 5ng/ml R00 exp35 | 1.9 |
| RO-3307 4.7μM R02 exp80 | 1.91 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7189
- Expression level (log2 read counts): 3.25
Expression Distribution
FLT3LG Expression in NALM6 Cells: 3.25
