FNBP1L [The Human Chemical-Genetic Interaction Map Project]

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======= FNBP1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FNBP1L
  * **<color #00a2e8>Official Name</color>**: formin binding protein 1 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54874|54874]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T0N5|Q5T0N5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FNBP1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FNBP1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH3 2|
|FCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle transport along actin filament|
|actin filament-based transport|
|plasma membrane tubulation|
|clathrin-dependent endocytosis|
|positive regulation of filopodium assembly|
|GTPase binding|
|regulation of filopodium assembly|
|vesicle cytoskeletal trafficking|
|plasma membrane organization|
|vesicle budding from membrane|
|positive regulation of plasma membrane bounded cell projection assembly|
|actin filament-based movement|
|cell cortex|
|membrane invagination|
|lipid binding|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|vesicle localization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|receptor-mediated endocytosis|
|cytoplasmic vesicle|
|process utilizing autophagic mechanism|
|autophagy|
|vesicle organization|
|cadherin binding|
|cilium assembly|
|establishment of organelle localization|
|cytoskeleton|
|cilium organization|
|positive regulation of cell projection organization|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of cellular component biogenesis|
|endocytosis|
|actin filament-based process|
|organelle localization|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|organelle assembly|
|membrane organization|
|regulation of cellular component biogenesis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|intracellular transport|
|movement of cell or subcellular component|
|cellular catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.08|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FNBP1L Expression in NALM6 Cells: 4.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>